KEGG   Mus musculus (house mouse): 22637
Entry
22637             CDS       T01002                                 
Symbol
Zap70, Srk, ZAP-70, mrtle, mur
Name
(RefSeq) zeta-chain (TCR) associated protein kinase
  KO
K07360  tyrosine-protein kinase ZAP-70 [EC:2.7.10.2]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu04014  Ras signaling pathway
mmu04064  NF-kappa B signaling pathway
mmu04650  Natural killer cell mediated cytotoxicity
mmu04658  Th1 and Th2 cell differentiation
mmu04659  Th17 cell differentiation
mmu04660  T cell receptor signaling pathway
mmu05135  Yersinia infection
mmu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mmu05340  Primary immunodeficiency
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    22637 (Zap70)
   04064 NF-kappa B signaling pathway
    22637 (Zap70)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    22637 (Zap70)
   04660 T cell receptor signaling pathway
    22637 (Zap70)
   04658 Th1 and Th2 cell differentiation
    22637 (Zap70)
   04659 Th17 cell differentiation
    22637 (Zap70)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    22637 (Zap70)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    22637 (Zap70)
  09163 Immune disease
   05340 Primary immunodeficiency
    22637 (Zap70)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    22637 (Zap70)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     22637 (Zap70)
Protein kinases [BR:mmu01001]
 Non-receptor tyrosine kinases
  SYK family
   22637 (Zap70)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SH2 ABC1 Haspin_kinase Kdo
Other DBs
NCBI-GeneID: 22637
NCBI-ProteinID: NP_001276694
MGI: 99613
Ensembl: ENSMUSG00000026117
UniProt: P43404
Position
1:36800912..36821899
AA seq 618 aa
MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP
IERQLNGTYAIAGGKAHCGPAELCQFYSQDPDGLPCNLRKPCNRPPGLEPQPGVFDCLRD
AMVRDYVRQTWKLEGDALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG
QQTDGKFLLRPRKEQGTYALSLVYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK
LKADGLIYRLKEVCPNSSASAAVAAPTLPAHPSTFTQPQRRVDTLNSDGYTPEPARLASS
TDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRENLLVADIELGCGNFGSVRQGVYRMRK
KQIDVAIKVLKQGTEKADKDEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGP
LHKFLLGKKEEIPVSNVAELLHQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFG
LSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAFSYGQKPYK
KMKGPEVLDFIKQGKRMECPPECPPEMYALMSDCWIYKWEDRPDFLTVEQRMRNYYYSLA
SRAEGPPQCEQVAEAACG
NT seq 1857 nt   +upstreamnt  +downstreamnt
atgcccgatcccgcggcgcacctgccattcttctatggcagcatctcgcgggctgaggcc
gaggagcacctgaagctggcaggcatggccgacgggctgttcctcctgcgccagtgtttg
cgctccctgggcggctacgtgctgtcgttggtgcacgacgtgcgcttccaccatttcccc
atcgagcgccaactcaacggcacgtacgccatcgcgggcgggaaggcgcactgcggcccg
gccgagctctgccagttctactctcaggaccccgacgggctgccctgcaacctgcgtaag
ccgtgtaaccggccgcccggactggagccacagcccggggtcttcgactgcctgcgtgat
gctatggtgcgcgactacgtgcgccagacctggaagctggagggcgatgcactagagcag
gccatcatcagccaggccccacaggtggagaagctcattgctaccacagcccacgagcga
atgccctggtatcacagcagcctgactcgtgaggaggccgagcgcaaactctattccggc
cagcagaccgacggcaagttcctgctgaggccccggaaggagcagggcacatatgcactg
tccctggtctatgggaaaactgtataccactatctcatcagccaggacaaggctggcaag
tactgcatccccgaaggcaccaagtttgacacgctctggcagctggtggagtacctgaag
ctgaaggcggatggactaatttaccgcttgaaggaggtctgtcccaacagcagcgccagc
gcggcagttgctgcacccaccctcccagcccacccatccacattcactcagcctcagaga
cgagtggacaccctgaactcggacggatacacccctgaaccagcacgcttagcgtcatcg
acagacaagccccggccgatgcccatggacacaagtgtgtacgagagtccctacagcgac
cctgaggaactcaaagacaagaagctcttcctgaagcgagagaatctcctcgtggcggac
atcgagcttggctgtggcaactttggctccgtgcgccagggagtctatcgcatgcgcaag
aagcagattgacgtggccatcaaggtgctgaagcagggcacagagaaggccgacaaagat
gagatgatgcgagaggcccagatcatgcaccagctcgacaacccctacatcgtgcggctc
atcggcgtgtgccaggcagaagcactcatgctggtcatggagatggcgggaggcgggccc
ctgcacaagttcctgctgggaaagaaggaggagatccctgtgagcaatgtggctgaactg
ctgcaccaggtggccatgggcatgaagtatttggaggagaaaaactttgtgcaccgcgac
ctggcagcccgcaatgttctactggtcaatcggcactatgccaagatcagcgactttggc
ctgtccaaagccctgggtgctgacgacagctattacacagcccggtctgcagggaagtgg
cctctgaagtggtacgcgccagagtgcatcaactttcggaagttctccagccgcagtgac
gtctggagctatggggtcaccatgtgggaggccttctcctatggccagaagccctacaag
aaaatgaagggccccgaggtcctggacttcatcaagcagggtaagaggatggaatgtccg
ccggagtgtcctcctgagatgtatgcacttatgagtgactgctggatctacaagtgggag
gatcgccccgacttcctgactgtggaacaacgtatgcggaactattactacagcctggcc
agccgggccgagggacccccacagtgtgaacaggtggccgaggctgcatgtggctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (9)   
   KEGG PATHWAY (9)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (9)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (23)   
   RefSeq(nuc) (5)   
   GenBank (9)   
   EMBL (9)   
Protein domain (6)   
   Pfam (6)   
All databases (59)   

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